Lilly Uses Horny Goat Weed to Fend Off Cialis Royalty Demands

Eli Lilly & Co. told a federal jury that a German company is trying to take credit for centuries-old Chinese medicine in seeking royalties on the use of its erectile-dysfunction drug Cialis to treat an enlarged prostate.

Erfindergemeinschaft UroPep GbR, a company founded by researchers from Hannover Medical School, claims it’s entitled to royalties from Lilly’s sale of Cialis based on a patent for prostate treatment. UroPep is seeking $84.3 million, or 12 percent of the $704 million in Cialis sales since 2011 that relate to its use in treating benign prostatic hyperplasia, also known as BPH.

“We offered to give Eli Lilly permission” to use the patented invention, UroPep lawyer John Hughes of Bartlit Beck in Denver told a federal jury in Marshall, Texas. “Their response: silence.”

Lilly said the patent didn’t cover anything new — and pointed to Chinese home remedies including one known as Horny Goat Weed, which it said is used both for erectile dysfunction and to treat BPH. It’s not the first time Lilly has brought up the herb — it was used to successfully invalidate part of a Pfizer Inc. patent for the rival impotence drug Viagra.

“UroPep filed a patent with nothing more than an idea,” Lilly lawyer Todd Vare of Barnes & Thornburg in Indianapolis told the jury. The idea “is well-known and obvious throughout the world.”

The drug, more commonly prescribed for erectile dysfunction, generated almost $2.5 billion last year, more than 11 percent of the Indianapolis-based company’s revenue. It’s Lilly’s second-biggest seller, behind the insulin Humalog, used to treat diabetes. Hughes told the jury that UroPep was not seeking royalties on any sales of Cialis for impotence.

The UroPep patent, issued in the U.S. in 2014, is for the use of a class of compounds to treat certain prostate diseases, including BPH. Lilly contends the patent doesn’t cover the specific active ingredient in Cialis, called tadalafil.

Cialis was approved by U.S. regulators to treat erectile dysfunction in 2008 and in December 2010 Lilly asked the U.S. Food and Drug Administration to also approve Cialis for treatment of the signs and symptoms of BPH.

After Lilly got approval, one of the UroPep inventors emailed Lilly to inform it of the then-pending patent application. Lilly didn’t respond to requests for licensing talks, UroPep contends.

This isn’t the only case in which Lilly is trying to fend off royalty demands from Cialis. The drugmaker is working to invalidate a patent owned by Los Angeles Biomedical Research Institute for a method of arresting penile fibrosis.

Presiding over the trial is Circuit Judge William Bryson, who occasionally handles district court cases but normally sits on the U.S. Court of Appeals for the Federal Circuit in Washington, which handles all patent appeals. While neither Lilly nor UroPep are based in Texas, the case was filed there because the court is the most popular for patent litigation.

The jury is expected to begin deliberations by Friday.

The case is Erfindergemeinschaft UroPep GbR v. Eli Lilly & Co., 15cv1202, U.S, District Court for the Eastern District of Texas (Marshall).

Read more: http://www.bloomberg.com/news/articles/2017-04-17/lilly-uses-horny-goat-weed-to-fend-off-cialis-royalty-demands

Lilly Uses Horny Goat Weed to Fend Off Cialis Royalty Demands

Eli Lilly & Co. told a federal jury that a German company is trying to take credit for centuries-old Chinese medicine in seeking royalties on the use of its erectile-dysfunction drug Cialis to treat an enlarged prostate.

Erfindergemeinschaft UroPep GbR, a company founded by researchers from Hannover Medical School, claims it’s entitled to royalties from Lilly’s sale of Cialis based on a patent for prostate treatment. UroPep is seeking $84.3 million, or 12 percent of the $704 million in Cialis sales since 2011 that relate to its use in treating benign prostatic hyperplasia, also known as BPH.

“We offered to give Eli Lilly permission” to use the patented invention, UroPep lawyer John Hughes of Bartlit Beck in Denver told a federal jury in Marshall, Texas. “Their response: silence.”

Lilly said the patent didn’t cover anything new — and pointed to Chinese home remedies including one known as Horny Goat Weed, which it said is used both for erectile dysfunction and to treat BPH. It’s not the first time Lilly has brought up the herb — it was used to successfully invalidate part of a Pfizer Inc. patent for the rival impotence drug Viagra.

“UroPep filed a patent with nothing more than an idea,” Lilly lawyer Todd Vare of Barnes & Thornburg in Indianapolis told the jury. The idea “is well-known and obvious throughout the world.”

The drug, more commonly prescribed for erectile dysfunction, generated almost $2.5 billion last year, more than 11 percent of the Indianapolis-based company’s revenue. It’s Lilly’s second-biggest seller, behind the insulin Humalog, used to treat diabetes. Hughes told the jury that UroPep was not seeking royalties on any sales of Cialis for impotence.

The UroPep patent, issued in the U.S. in 2014, is for the use of a class of compounds to treat certain prostate diseases, including BPH. Lilly contends the patent doesn’t cover the specific active ingredient in Cialis, called tadalafil.

Cialis was approved by U.S. regulators to treat erectile dysfunction in 2008 and in December 2010 Lilly asked the U.S. Food and Drug Administration to also approve Cialis for treatment of the signs and symptoms of BPH.

After Lilly got approval, one of the UroPep inventors emailed Lilly to inform it of the then-pending patent application. Lilly didn’t respond to requests for licensing talks, UroPep contends.

This isn’t the only case in which Lilly is trying to fend off royalty demands from Cialis. The drugmaker is working to invalidate a patent owned by Los Angeles Biomedical Research Institute for a method of arresting penile fibrosis.

Presiding over the trial is Circuit Judge William Bryson, who occasionally handles district court cases but normally sits on the U.S. Court of Appeals for the Federal Circuit in Washington, which handles all patent appeals. While neither Lilly nor UroPep are based in Texas, the case was filed there because the court is the most popular for patent litigation.

The jury is expected to begin deliberations by Friday.

The case is Erfindergemeinschaft UroPep GbR v. Eli Lilly & Co., 15cv1202, U.S, District Court for the Eastern District of Texas (Marshall).

Read more: http://www.bloomberg.com/news/articles/2017-04-17/lilly-uses-horny-goat-weed-to-fend-off-cialis-royalty-demands

Tamsulosin a Prescription Medication Used to Treat the Symptoms of Enlarged Prostate – Overview

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Tamsulosin is a prescription medication used to treat the symptoms of enlarged prostate, known medically as benign prostatic hyperplasia, or BPH. Tamsulosin is in a class of medications called alpha blockers. It works by relaxing the muscles in the prostate and bladder so that urine can flow easily. This medication comes as a capsule that is taken by mouth once a day. It should be taken 30 minutes after the same meal each day. Common side effects include runny nose, dizziness, and decreased semen count.

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. Generally Enlarged Prostate Gland is also called as Benign Prostatic Hyperplasia (BPH) or Prostatic Hypertrophy. It is a common condition as men get older. Prostate Care Pack is a special formulation of Planet Ayurveda is an effective ayurvedic medicine for Prostate Enlargement. These herbal remedies are very effective and have no side effects.

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As a man ages, it is not uncommon to experience prostate gland enlargement. Also known as benign prostatic hyperplasia, this condition is often accompanied by bothersome urinary symptoms. If the condition is mild, it can often be treated by the simple lifestyle changes described here.

Warning
Consult your doctor if you are having urination problems. Seek immediate medical treatment if you are unable to pass urine at all.

Step 1: Urinate as needed
Urinate as soon as you feel the urge. Try to urinate again a few moments later.

Tip
Consult your doctor if you take diuretics.

Step 2: Drink liquids in moderation
Drink liquids in moderation, spreading out your fluid intake during the day. Do not drink liquids within two hours of bedtime.

Step 3: Urinate at regular intervals
Urinate at regular times during the day – preferably every four to six hours – to retrain the bladder.

Step 4: Avoid alcohol and caffeine
Avoid alcohol and caffeine, especially in the evening.

Step 5: Avoid decongestants and antihistamines
Avoid, as much as possible, over-the-counter cold and sinus medications that contain decongestants or antihistamines.

Step 6: Avoid cold weather
Avoid cold weather and try to stay warm. Cold temperatures can lead to urine retention.

Step 7: Reduce stress
Avoid unnecessary stress. If you are nervous or tense, you will need to urinate more frequently.

Did You Know?
Plant-derived substances such as saw palmetto have been widely used to treat benign prostatic hyperplasia in Europe.

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Information on this video is provided for interest & information only & does not constitute any kind of advice. Guava leaves is said to be very beneficial to treat diarrhea, combat prostate enlargement & prostate cancer for men.

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Dr Raj explains what BPH is and best how to deal with the problems like hesitancy, urgency, prostate, and problems associated with the prostate.

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Urologist Michael White, D.O. explains a common problem among men, enlarged prostate, and how it can lead to bladder infections, stones, blood in the urine and kidney damage. Richard had the largest prostate Dr. White had ever seen, so he became the first person in South Teas to undergo a Robotic Simple Prostatectomy.

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Learn about natural treatment for prostate enlargement (BPH), prostatitis & prostate cancer prevention. Dr. Meschino explains what the causes are & provides natural management & prevention solutions.
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It's quite literally a growing problem among men in this country.

"Forty-percent of 40-year-old men have enlarged prostate, 50 percent of 50-year-old men have enlarged prostate and 60 percent of 60-year-old men have enlarge prostate," says Dr. Meir Daller, a urologist on the medical staff of Lee Memorial Health System.

A condition called benign prostate hyperplasia can cause extreme discomfort. As the prostate gland increases in size, it puts pressure or squeezes the urethra, and causes a variety of urinary problems.

"Waking up at night several times, two or three times at night. You have difficulty falling asleep again, you have dribbling, you have weaker stream, you have a hesitancy. Some of the complications from urinary retention are urinary tract infection, bladder stones, and kidney failure. These are serious complications that can happen if you're not able to empty your bladder very well," says Dr. Daller.

The gold standard used to be removing part of the enlarged prostate. It was a significant surgery that required hospital stay. Now a new procedure is being done in outpatient surgery centers, and it doesn't involve cutting.

"In this new procedure, you're using a special gas that essentially vaporizes the insides of the prostate and the end result is the same," says Dr. Daller.

Urologist Meir Daller uses a plasma vaporization electrode that doesn't cut the tissue. Instead it vaporizes it with a small button electrode.

"With the button the plasma button, this is essentially a virtually a bloodless procedure. The procedure itself takes about twenty minutes. The patient goes home about an hour after the procedure and overall they do quite well," says Dr. Daller.

The procedure is most commonly used on men who are not getting relief from medications. In those cases, the plasma procedure can vaporize their prostate problem.

View More Health Matters video segments at leememorial.org/healthmatters/

Lee Memorial Health System in Fort Myers, FL is the largest network of medical care facilities in Southwest Florida and is highly respected for its expertise, innovation and quality of care. For nearly a century, we've been providing our community with everything from primary care treatment to highly specialized care services and robotic assisted surgeries.

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